Mitochondrial aberrations and ophthalmic diseases
نویسندگان
چکیده
منابع مشابه
Mitochondrial aberrations and ophthalmic diseases
In this review, we comprehensively describe ophthalmic diseases with mitochondrial DNA mutation such as Leber's hereditary optic neuropathy (LHON), progressive external ophthalmoplegia (PEO) and Kearns-Sayre Syndrome (KSS). Ocular involvement is a prominent clinical feature of various mitochondrial diseases as well. The known mitochondrial disorders such as Mitochondrial encephalomyopathy, lact...
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Mitochondria are important intracellular organelles that produce energy for cellular development, differentiation, and growth. Mitochondrial DNA (mtDNA) presents a 10- to 20-fold higher susceptibility to genetic mutations owing to the lack of introns and histone proteins. The mtDNA repair system is relatively inefficient, rendering it vulnerable to reactive oxygen species (ROS) produced during ...
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ژورنال
عنوان ژورنال: Journal of Translational Science
سال: 2016
ISSN: 2059-268X
DOI: 10.15761/jts.1000167